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Molecular Profile | TP53 R248Q |
Therapy | APR-246 + Cisplatin |
Indication/Tumor Type | ovarian cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 R248Q | ovarian cancer | sensitive | APR-246 + Cisplatin | Preclinical | Actionable | In a preclinical study, the combination of APR-246 and Platinol (cisplatin) worked synergistically to inhibit growth of a Platinol (cisplatin)-resistant ovarian cancer cell line harboring TP53 R248Q in culture and inhibited tumor growth in TP53 R248Q-carrying ovarian cancer cell line xenograft models (PMID: 26086967). | 26086967 |
PubMed Id | Reference Title | Details |
---|---|---|
(26086967) | APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells. | Full reference... |