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| Molecular Profile | JAK2 R683G JAK2 L884P |
| Therapy | CHZ868 |
| Indication/Tumor Type | hematologic cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK2 R683G JAK2 L884P | hematologic cancer | resistant | CHZ868 | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing JAK2 R683G and L884P were resistant to CHZ868 in culture (PMID: 26175414). | 26175414 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26175414) | Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia. | Full reference... |