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| Molecular Profile | KIT V560_Y578del KIT V654A |
| Therapy | IDRX-42 |
| Indication/Tumor Type | gastrointestinal stromal tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT V560_Y578del KIT V654A | gastrointestinal stromal tumor | sensitive | IDRX-42 | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, IDRX-42 inhibited viability of a gastrointestinal stromal tumor cell line harboring KIT V560_Y578del and KIT V654A in culture, and resulted in tumor shrinkage in a cell line xenograft model and a complete response in a patient-derived xenograft (PDX) model (PMID: 40018846). | 40018846 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (40018846) | M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer. | Full reference... |