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| Molecular Profile | FLT3 exon 14 ins TP53 wild-type |
| Therapy | Milademetan + Quizartinib |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins TP53 wild-type | acute myeloid leukemia | sensitive | Milademetan + Quizartinib | Phase I | Actionable | In a Phase I trial, combination of Vanflyta (quizartinib) and Milademetan led to a complete response with incomplete hematologic recovery (CRi) in 40% (4/10) and stable disease (SD) in 30% of patients with TP53 wild-type acute myeloid leukemia harboring a FLT3-ITD, with a CRi of 50% (3/6) at the recommended dose; and the combination inhibited Flt3 signaling and synergistically induced apoptosis in culture and decreased leukemia growth in a cell line xenograft model (PMID: 40327322; NCT03552029). | 40327322 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (40327322) | Synergistic Activity of Combined FLT3-ITD and MDM2 Inhibition with Quizartinib and Milademetan in FLT3-ITD Mutant/TP53 Wild-type Acute Myeloid Leukemias. | Full reference... |