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Molecular Profile ATM R3008H KIT V559D KIT D579del KIT D820Y KIT A829P
Therapy Olaparib + Ripretinib
Indication/Tumor Type gastrointestinal stromal tumor
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM R3008H KIT V559D KIT D579del KIT D820Y KIT A829P gastrointestinal stromal tumor predicted - sensitive Olaparib + Ripretinib Case Reports/Case Series Actionable In a clinical case study, treatment with the combination of Lynparza (olaparib) and Qinlock (ripretinib) resulted in stable disease with a progression-free survival of 6.2 months in a patient with recurrent gastrointestinal stromal tumor harboring KIT V559D, D579del, D820Y, and A829P and ATM R3008H (PMID: 40700673; NCT0253467). 40700673
PubMed Id Reference Title Details
(40700673) Personalized N-of-1 Combination Therapies for Advanced Gastrointestinal Stromal Tumors. Full reference...