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| Molecular Profile | BRAF G596R |
| Therapy | JAB-3312 |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF G596R | colorectal cancer | sensitive | JAB-3312 | Preclinical - Cell culture | Actionable | In a preclinical study, JAB-3312 inhibited viability of a colorectal cancer cell line harboring BRAF G596R in culture (PMID: 40333694). | 40333694 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (40333694) | JAB-3312, a Potent Allosteric SHP2 Inhibitor That Enhances the Efficacy of RTK/RAS/MAPK and PD-1 Blockade Therapies. | Full reference... |