Therapy Detail
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| Therapy Name | JAB-3312 |
| Synonyms | |
| Therapy Description |
JAB-3312 is a SHP2 inhibitor, which potentially decreases tumor growth (PMID: 40304209). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| JAB-3312 | JAB3312|JAB 3312|sitneprotafib | SHP2 Inhibitor 20 | JAB-3312 is a SHP2 inhibitor, which potentially decreases tumor growth (PMID: 40304209). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins | leukemia | sensitive | JAB-3312 | Preclinical - Cell culture | Actionable | In a preclinical study, JAB-3312 inhibited viability of leukemia cell lines harboring a FLT3-ITD mutation in culture (PMID: 40333694). | 40333694 |
| BRAF G466V | lung non-small cell carcinoma | sensitive | JAB-3312 | Preclinical - Cell culture | Actionable | In a preclinical study, JAB-3312 inhibited viability of a non-small cell lung cancer cell line harboring BRAF G466V in culture (PMID: 40333694). | 40333694 |
| BRAF G596R | colorectal cancer | sensitive | JAB-3312 | Preclinical - Cell culture | Actionable | In a preclinical study, JAB-3312 inhibited viability of a colorectal cancer cell line harboring BRAF G596R in culture (PMID: 40333694). | 40333694 |
| NRAS R68T NRAS D92N | head and neck cancer | sensitive | JAB-3312 | Preclinical - Cell culture | Actionable | In a preclinical study, JAB-3312 inhibited viability of a head and neck cancer cell line harboring NRAS D92N and R68T in culture (PMID: 40333694). | 40333694 |
| FGFR1 amp FGFR2 amp | breast carcinoma | sensitive | JAB-3312 | Preclinical - Cell culture | Actionable | In a preclinical study, JAB-3312 inhibited viability of an FGFR1 and FGFR2-amplified invasive breast carcinoma cell line in culture (PMID: 40333694). | 40333694 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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