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| Molecular Profile | KIT Q575_P577delinsH |
| Therapy | Imatinib |
| Indication/Tumor Type | gastrointestinal stromal tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT Q575_P577delinsH | gastrointestinal stromal tumor | predicted - sensitive | Imatinib | Case Reports/Case Series | Actionable | In a clinical study, Gleevec (imatinib) treatment resulted in partial responses in 2 patients with metastatic rectal gastrointestinal stromal tumor harboring germline KIT Q575_P577delinsH, with treatment ongoing for at least 58 months in one patient and disease stabilization ongoing for at least 12 months in the second patient (PMID: 18183595). | 18183595 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (18183595) | Rectal gastrointestinal stromal tumors associated with a novel germline KIT mutation. | Full reference... |