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| Molecular Profile | RAD51C T121R |
| Therapy | Olaparib |
| Indication/Tumor Type | osteosarcoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RAD51C T121R | osteosarcoma | sensitive | Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, Lynparza (olaparib) treatment inhibited viability of an osteosarcoma cell line expressing RAD51C T121R in culture (PMID: 36099300). | 36099300 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36099300) | Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants. | Full reference... |