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| Molecular Profile | APC inact mut |
| Therapy | E7386 |
| Indication/Tumor Type | desmoid tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC inact mut | desmoid tumor | predicted - sensitive | E7386 | Case Reports/Case Series | Actionable | In a Phase I trial, E7386 treatment demonstrated manageable safety and resulted in 2 partial responses in 55 patients with advanced solid tumors, including a partial response with treatment lasting 7.5 months in a patient with small bowel carcinoma and a partial response with treatment lasting 3.5 years in a patient with desmoid tumor (PMID: 41385966; NCT03833700). | 41385966 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (41385966) | E7386 in patients with advanced solid tumors: results from the dose-escalation part and an expansion part of a phase I study. | Full reference... |