Therapy Detail
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| Therapy Name | E7386 |
| Synonyms | |
| Therapy Description |
E7386 inhibits the interaction between CBP and beta-catenin, resulting in decreased Wnt pathway signaling and potentially leading to alteration of the tumor microenvironment and decreased tumor growth (PMID: 33408116). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| E7386 | E 7386|E-7386 | WNT Inhibitor 17 | E7386 inhibits the interaction between CBP and beta-catenin, resulting in decreased Wnt pathway signaling and potentially leading to alteration of the tumor microenvironment and decreased tumor growth (PMID: 33408116). |
Filtering
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC inact mut | desmoid tumor | predicted - sensitive | E7386 | Case Reports/Case Series | Actionable | In a Phase I trial, E7386 treatment demonstrated manageable safety and resulted in 2 partial responses in 55 patients with advanced solid tumors, including a partial response with treatment lasting 7.5 months in a patient with small bowel carcinoma and a partial response with treatment lasting 3.5 years in a patient with desmoid tumor (PMID: 41385966; NCT03833700). | 41385966 |
| APC inact mut | small intestine carcinoma | predicted - sensitive | E7386 | Case Reports/Case Series | Actionable | In a Phase I trial, E7386 treatment demonstrated manageable safety and resulted in 2 partial responses in 55 patients with advanced solid tumors, including a partial response with treatment lasting 7.5 months in a patient with small bowel carcinoma and a partial response with treatment lasting 3.5 years in a patient with desmoid tumor (PMID: 41385966; NCT03833700). | 41385966 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03264664 | Phase I | E7386 | Study of E7386 in Participants With Selected Advanced Neoplasms | Active, not recruiting | USA | GBR | 0 |
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