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Molecular Profile KIT exon17
Therapy Imatinib
Indication/Tumor Type gastrointestinal stromal tumor
Response Type resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT exon17 gastrointestinal stromal tumor resistant Imatinib Clinical Study - Meta-analysis Actionable In a meta-analysis, KIT exon 17 mutations were identified upon progression with Gleevec (imatinib) in 54.5% of patients with gastrointestinal stromal tumors harboring a primary KIT mutation (n=92) (PMID: 24369323). 24369323
PubMed Id Reference Title Details
(24369323) Correlation of imatinib resistance with the mutational status of KIT and PDGFRA genes in gastrointestinal stromal tumors: a meta-analysis. Full reference...