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| Molecular Profile | IDH1 R132L |
| Therapy | AGI-5198 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH1 R132L | Advanced Solid Tumor | predicted - sensitive | AGI-5198 | Preclinical - Biochemical | Actionable | In a preclinical study, AGI-5198 inhibited the activity of IDH1 R132L in an in vitro assay (PMID: 30249606). | 30249606 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (30249606) | Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants. | Full reference... |