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Molecular Profile | EML4 - ALK ALK G1269A |
Therapy | Alectinib |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
EML4 - ALK ALK G1269A | lung non-small cell carcinoma | sensitive | Alectinib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with EML4-ALK fusion positive non-small cell lung cancer with ALK G1269A had a partial response to Alecensa (alectinib) treatment (PMID: 26849637). | 26849637 |
EML4 - ALK ALK G1269A | lung non-small cell carcinoma | sensitive | Alectinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Alecensa (alectinib) inhibited proliferation of a Xalkori (crizotinib)-resistant human non-small cell lung cancer cell line harboring an EML-ALK fusion with ALK G1269A in culture and induced tumor regression in cell line xenograft models (PMID: 26849637, PMID: 23344087). | 26849637 23344087 |
PubMed Id | Reference Title | Details |
---|---|---|
(23344087) | Heterogeneity of genetic changes associated with acquired crizotinib resistance in ALK-rearranged lung cancer. | Full reference... |
(26849637) | Antitumor activity of alectinib, a selective ALK inhibitor, in an ALK-positive NSCLC cell line harboring G1269A mutation: Efficacy of alectinib against ALK G1269A mutated cells. | Full reference... |
(26849637) | Antitumor activity of alectinib, a selective ALK inhibitor, in an ALK-positive NSCLC cell line harboring G1269A mutation: Efficacy of alectinib against ALK G1269A mutated cells. | Full reference... |