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Molecular Profile | PTEN A126G |
Therapy | AZD6482 |
Indication/Tumor Type | prostate cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN A126G | prostate cancer | sensitive | AZD6482 | Preclinical | Actionable | In a preclinical study, AZD6482 inhibited Akt signaling and cell migration in prostate cancer cell lines overexpressing PTEN A126G (PMID: 26504226). | 26504226 |
PubMed Id | Reference Title | Details |
---|---|---|
(26504226) | Discovery and functional characterization of a neomorphic PTEN mutation. | Full reference... |