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Therapy Name	AZD6482
Synonyms
Therapy Description	AZD6482 inhibits PIK3CB and PIK3CD, preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival (PMID: 24992874, PMID: 23674493, PMID: 31292159, PMID: 30542720).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
AZD6482		KIN-193\|AZD-6482	PIK3CB inhibitor 8 PIK3CD inhibitor 27	AZD6482 inhibits PIK3CB and PIK3CD, preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival (PMID: 24992874, PMID: 23674493, PMID: 31292159, PMID: 30542720).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
ATM loss	chronic lymphocytic leukemia	sensitive	AZD6482	Preclinical	Actionable	In a preclinical study, AZD6482 induced cell death in ATM-deficient chronic lymphocytic leukemia cells in culture and inhibited tumor growth in xenograft models (PMID: 26563132).	26563132
BRAF mut PTEN inact mut	melanoma	sensitive	AZD6482	Preclinical	Actionable	In a preclincal study, AZD6482 inhibited Akt activation and proliferation in melanoma cell lines harboring BRAF mutations and PTEN inactivating mutations in culture (PMID: 26577700).	26577700
PTEN A126G	prostate cancer	sensitive	AZD6482	Preclinical	Actionable	In a preclinical study, AZD6482 inhibited Akt signaling and cell migration in prostate cancer cell lines overexpressing PTEN A126G (PMID: 26504226).	26504226
PTEN loss	breast cancer	sensitive	AZD6482	Preclinical	Actionable	In a preclinical study, AZD6482 inhibited viability of breast cancer cell lines harboring PTEN deficiency in culture (PMID: 23674493).	23674493
PTEN loss	prostate cancer	sensitive	AZD6482	Preclinical	Actionable	In a preclinical study, AZD6482 inhibited viability of prostate cancer cell lines harboring PTEN deficiency in culture (PMID: 23674493).	23674493
PTEN mutant	endometrial cancer	resistant	AZD6482	Preclinical	Actionable	In a preclinical study, endometrioid endometrial cancer cell lines harboring PTEN mutations demonstrated resistance to AZD6482 induced growth inhibition in culture (PMID: 23674493).	23674493
TP53 inact mut	chronic lymphocytic leukemia	predicted - sensitive	AZD6482	Preclinical	Actionable	In a preclinical study, AZD6482 induced cell death in TP53-deficient chronic lymphocytic leukemia cells in culture and inhibited tumor growth in xenograft models (PMID: 26563132).	26563132

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