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Molecular Profile | RET C634Y |
Therapy | HG-6-63-01 |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET C634Y | Advanced Solid Tumor | sensitive | HG-6-63-01 | Preclinical | Actionable | In a preclinical study, HG-6-63-01 inhibited RET phosphorylation and downstream signaling and reduced proliferation of transformed cells expressing RET C634Y in culture (PMID: 26046350). | 26046350 |
PubMed Id | Reference Title | Details |
---|---|---|
(26046350) | Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase. | Full reference... |