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Therapy Name	HG-6-63-01
Synonyms
Therapy Description	HG-6-63-01 inhibits RET, resulting in decreased downstream signaling and reduced tumor cell proliferation (PMID: 26046350).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
HG-6-63-01			RET Inhibitor 53	HG-6-63-01 inhibits RET, resulting in decreased downstream signaling and reduced tumor cell proliferation (PMID: 26046350).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
RET C634W	medullary thyroid carcinoma	sensitive	HG-6-63-01	Preclinical	Actionable	In a preclinical study, HG-6-63-01 inhibited RET phosphorylation and downstream signaling and reduced proliferation of medullary thyroid carcinoma cells harboring RET C634W in culture (PMID: 26046350).	26046350
RET C634Y	Advanced Solid Tumor	sensitive	HG-6-63-01	Preclinical	Actionable	In a preclinical study, HG-6-63-01 inhibited RET phosphorylation and downstream signaling and reduced proliferation of transformed cells expressing RET C634Y in culture (PMID: 26046350).	26046350
RET M918T	Advanced Solid Tumor	sensitive	HG-6-63-01	Preclinical	Actionable	In a preclinical study, HG-6-63-01 inhibited RET phosphorylation and downstream signaling and reduced proliferation of transformed cells expressing RET M918T in culture (PMID: 26046350).	26046350
RET M918T	medullary thyroid carcinoma	sensitive	HG-6-63-01	Preclinical	Actionable	In a preclinical study, HG-6-63-01 inhibited RET phosphorylation and downstream signaling and reduced proliferation of medullary thyroid carcinoma cells harboring RET M918T in culture (PMID: 26046350).	26046350

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