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| Molecular Profile | RET C634W |
| Therapy | HG-6-63-01 |
| Indication/Tumor Type | medullary thyroid carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET C634W | medullary thyroid carcinoma | sensitive | HG-6-63-01 | Preclinical | Actionable | In a preclinical study, HG-6-63-01 inhibited RET phosphorylation and downstream signaling and reduced proliferation of medullary thyroid carcinoma cells harboring RET C634W in culture (PMID: 26046350). | 26046350 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26046350) | Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase. | Full reference... |