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| Molecular Profile | PIK3CA H1047Y |
| Therapy | YM-024 |
| Indication/Tumor Type | glioblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA H1047Y | glioblastoma | sensitive | YM-024 | Preclinical | Actionable | In a preclinical study, glioblastoma cell lines harboring PIK3CA H1047Y demonstrated increased sensitivity to YM-024 induced growth inhibition (PMID: 24718026). | 24718026 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24718026) | Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma. | Full reference... |