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Molecular Profile | PIK3CA H1047Y |
Therapy | YM-024 |
Indication/Tumor Type | glioblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA H1047Y | glioblastoma | sensitive | YM-024 | Preclinical | Actionable | In a preclinical study, glioblastoma cell lines harboring PIK3CA H1047Y demonstrated increased sensitivity to YM-024 induced growth inhibition (PMID: 24718026). | 24718026 |
PubMed Id | Reference Title | Details |
---|---|---|
(24718026) | Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma. | Full reference... |