Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | PIK3CA over exp |
Therapy | YM-024 |
Indication/Tumor Type | glioblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PIK3CA over exp | glioblastoma | sensitive | YM-024 | Preclinical | Actionable | In a preclinical study, YM-024 inhibited proliferation and anchorage-independent growth of glioblastoma cell lines with elevated Pik3ca protein level in culture (PMID: 24718026). | 24718026 |
PubMed Id | Reference Title | Details |
---|---|---|
(24718026) | Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastoma. | Full reference... |