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Molecular Profile | STK11 D194E STK11 loss |
Therapy | Everolimus |
Indication/Tumor Type | pancreatic cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
STK11 D194E STK11 loss | pancreatic cancer | predicted - sensitive | Everolimus | Case Reports/Case Series | Actionable | In a clinical case study, a pancreatic cancer patient with Peutz-Jeghers syndrome harboring STK11 D194E and loss of heterozygosity of the other STK11 allele in the tumor achieved a partial response following treatment with Afinitor (everolimus), but progressed after 9 months (PMID: 21189378). | 21189378 |
PubMed Id | Reference Title | Details |
---|---|---|
(21189378) | mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome. | Full reference... |