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Molecular Profile | JAK2 amp |
Therapy | NVP-BSK805 + Paclitaxel |
Indication/Tumor Type | triple-receptor negative breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 amp | triple-receptor negative breast cancer | sensitive | NVP-BSK805 + Paclitaxel | Preclinical - Pdx | Actionable | In a preclinical study, NVP-BSK805 with Abraxane (paclitaxel) inhibited tumor growth in triple-negative breast cancer patient-derived xenograft models with JAK2 amplification (PMID: 27075627). | 27075627 |
PubMed Id | Reference Title | Details |
---|---|---|
(27075627) | Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence. | Full reference... |