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Molecular Profile | TP53 R280K |
Therapy | YW3-56 |
Indication/Tumor Type | triple-receptor negative breast cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 R280K | triple-receptor negative breast cancer | sensitive | YW3-56 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, YW3-56 inhibited proliferation of a human triple-negative breast cancer (TNBC) cell line harboring TP53 R280K in culture and inhibited tumor growth in TP53 R280K-mutant TNBC cell line xenograft models (PMID: 25612620). | 25612620 |
PubMed Id | Reference Title | Details |
---|---|---|
(25612620) | ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells. | Full reference... |