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| Molecular Profile | MAP2K1 K57N |
| Therapy | Trametinib |
| Indication/Tumor Type | lymphatic system cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MAP2K1 K57N | lymphatic system cancer | sensitive | Trametinib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with refractory Erdheim-Chester disease harboring a MAP2K1 K57N mutation had a sustained clinical response to Mekinist (trametinib) for over 6 months (PMID: 26566875). | 26566875 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26566875) | Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms. | Full reference... |