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ID | DOID:60073 |
Name | lymphatic system cancer |
Definition | An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer organ system cancer immune system cancer lymphatic system cancer |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
MAP2K1 K57N | Trametinib | lymphatic system cancer | sensitive | detail... |
BRAF V600E | Cobimetinib | lymphatic system cancer | predicted - sensitive | detail... |
BRAF N486_T491delinsK | Cobimetinib | lymphatic system cancer | predicted - sensitive | detail... |
MAP2K1 P124L | Cobimetinib | lymphatic system cancer | predicted - sensitive | detail... |
MAP2K1 P124Q | Cobimetinib | lymphatic system cancer | predicted - sensitive | detail... |
MAP2K1 P105_I107del | Cobimetinib | lymphatic system cancer | predicted - sensitive | detail... |
BRAF N486_P490del | Trametinib | lymphatic system cancer | predicted - sensitive | detail... |
MAP2K1 K57_G61del | Trametinib | lymphatic system cancer | predicted - sensitive | detail... |
MAP2K1 L98_K104delinsQ | Trametinib | lymphatic system cancer | predicted - resistant | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT03155620 | Phase II | Tazemetostat Larotrectinib LY3023414 Vemurafenib Palbociclib Olaparib Ulixertinib Erdafitinib Selumetinib Ensartinib | Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) | Recruiting | USA | CAN | AUS | 1 |