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Molecular Profile | IDH1 mutant |
Therapy | N/A |
Indication/Tumor Type | high grade glioma |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
IDH1 mutant | high grade glioma | not applicable | N/A | Guideline | Diagnostic | IDH1 mutations aid in the diagnosis of gliomas (PMID: 23041832, PMID: 19755387, PMID: 19915484; NCCN.org). | detail... 23041832 19755387 19915484 |
IDH1 mutant | high grade glioma | not applicable | N/A | Guideline | Prognostic | IDH1 mutations are associated with a favorable prognosis in patients with glioma, and are associated with a survival benefit for patients treated with radiation or alkylator therapy (NCCN.org). | detail... |
IDH1 mutant | high grade glioma | not applicable | N/A | Clinical Study | Prognostic | In multiple clinical studies, including two meta-analyses, IDH1 mutations were associated with improved overall survival and progression free survival in patients with gliomas (PMID: 23817809, PMID: 26220714, PMID: 23894344). | 23894344 23817809 26220714 |
PubMed Id | Reference Title | Details |
---|---|---|
(23817809) | A population-based study of low-grade gliomas and mutated isocitrate dehydrogenase 1 (IDH1). | Full reference... |
(26220714) | Prognostic role of IDH mutations in gliomas: a meta-analysis of 55 observational studies. | Full reference... |
(23894344) | IDH1/IDH2 mutations define the prognosis and molecular profiles of patients with gliomas: a meta-analysis. | Full reference... |
(23041832) | Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants. | Full reference... |
(19755387) | IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. | Full reference... |
(19915484) | Diagnostic use of IDH1/2 mutation analysis in routine clinical testing of formalin-fixed, paraffin-embedded glioma tissues. | Full reference... |
NCCN.org | Full reference... | |
NCCN.org | Full reference... |