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| Molecular Profile | KMT2A rearrange |
| Therapy | N/A |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | not applicable |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KMT2A rearrange | acute myeloid leukemia | not applicable | N/A | Guideline | Prognostic | KMT2A rearrangements (t(v;11q23.3)) are associated with a poor/adverse prognosis in patients with non-APL acute myeloid leukemia (NCCN.org). | detail... |
| KMT2A rearrange | acute myeloid leukemia | not applicable | N/A | Clinical Study | Prognostic | In multiple clinical studies, KMT2A rearrangements, specifically partial tandem duplications, were associated with a poor overall survival in acute myeloid leukemia patients (PMID: 24487413, PMID: 22915647, PMID: 22417203, PMID: 21881046). | 21881046 24487413 22417203 22915647 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (22915647) | A novel hierarchical prognostic model of AML solely based on molecular mutations. | Full reference... |
| (21881046) | Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. | Full reference... |
| (24487413) | Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients. | Full reference... |
| (22417203) | Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. | Full reference... |
| NCCN.org | Full reference... |