Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | KMT2A rearrange |
Therapy | N/A |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | not applicable |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A rearrange | acute myeloid leukemia | not applicable | N/A | Guideline | Prognostic | KMT2A rearrangements (t(v;11q23.3)) are associated with a poor/adverse prognosis in patients with non-APL acute myeloid leukemia (NCCN.org). | detail... |
KMT2A rearrange | acute myeloid leukemia | not applicable | N/A | Clinical Study | Prognostic | In multiple clinical studies, KMT2A rearrangements, specifically partial tandem duplications, were associated with a poor overall survival in acute myeloid leukemia patients (PMID: 24487413, PMID: 22915647, PMID: 22417203, PMID: 21881046). | 21881046 24487413 22417203 22915647 |
PubMed Id | Reference Title | Details |
---|---|---|
(22915647) | A novel hierarchical prognostic model of AML solely based on molecular mutations. | Full reference... |
(21881046) | Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia. | Full reference... |
(24487413) | Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients. | Full reference... |
(22417203) | Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. | Full reference... |
NCCN.org | Full reference... |