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| Molecular Profile | KIT C443S |
| Therapy | Imatinib |
| Indication/Tumor Type | mucosal melanoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KIT C443S | mucosal melanoma | sensitive | Imatinib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with mucosal melanoma harboring KIT C443S demonstrated a substantial response to Gleevec (imatinib) in the first two weeks and then developed progression at 15 weeks (PMID: 25003536). | 25003536 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (25003536) | Novel somatic KIT exon 8 mutation with dramatic response to imatinib in a patient with mucosal melanoma: a case report. | Full reference... |