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Molecular Profile | SMARCA4 mut TP53 mut |
Therapy | LY3009120 |
Indication/Tumor Type | adrenal gland cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
SMARCA4 mut TP53 mut | adrenal gland cancer | resistant | LY3009120 | Preclinical | Actionable | In a preclinical study, human adrenal gland cancer cells harboring SMARCA4 and TP53 mutations were resistant to LY3009120 mediated growth inhibition in culture (PMID: 26343583). | 26343583 |
PubMed Id | Reference Title | Details |
---|---|---|
(26343583) | Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers. | Full reference... |