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Molecular Profile | RB1 positive |
Therapy | Palbociclib |
Indication/Tumor Type | medulloblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RB1 positive | medulloblastoma | sensitive | Palbociclib | Preclinical - Pdx | Actionable | In a preclinical study, Ibrance (palbociclib) inhibited Rb1 phosphorylation in tumor tissues and improved survival in patient-derived intracranial xenograft models of medulloblastoma (PMID: 27012813). | 27012813 |
PubMed Id | Reference Title | Details |
---|---|---|
(27012813) | DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets. | Full reference... |