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| Molecular Profile | RB1 positive |
| Therapy | Palbociclib |
| Indication/Tumor Type | medulloblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RB1 positive | medulloblastoma | sensitive | Palbociclib | Preclinical - Pdx | Actionable | In a preclinical study, Ibrance (palbociclib) inhibited Rb1 phosphorylation in tumor tissues and improved survival in patient-derived intracranial xenograft models of medulloblastoma (PMID: 27012813). | 27012813 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27012813) | DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets. | Full reference... |