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ID DOID:50902
Name medulloblastoma
Definition An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor.
Source DiseaseOntology.org
Alt Ids DOID:4981 DOID:168 DOID:0060105 DOID:3858
Path disease disease of cellular proliferation cancer organ system cancer nervous system cancer central nervous system cancer brain cancer infratentorial cancer medulloblastoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
TP53 mutant JQ1 medulloblastoma decreased response detail...
TP53 wild-type JQ1 medulloblastoma sensitive detail...
RB1 positive Palbociclib medulloblastoma sensitive detail...
CTNNB1 mutant N/A medulloblastoma not applicable detail...
APC mutant N/A medulloblastoma not applicable detail...
TP53 mutant N/A medulloblastoma not applicable detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00089245 Phase I Omburtamab I-131 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer Terminated USA 0
NCT00601003 Phase II Cyclophosphamide + Nifurtimox + Topotecan Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma Completed USA 0
NCT00602667 Phase I Cisplatin + Cyclophosphamide + Methotrexate + Vincristine Sulfate Cyclophosphamide + Etoposide + Topotecan Cyclophosphamide + Erlotinib + Topotecan Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma Active, not recruiting USA | AUS 0
NCT00876993 Phase I Bevacizumab + Irinotecan + Temozolomide Study of Irinotecan and Bevacizumab With Temozolomide in Refractory/Relapsed Central Nervous System (CNS) Tumors Completed USA 0
NCT00983398 Phase Ib/II Pegfilgrastim Filgrastim Carboplatin + Melphalan Melphalan, Carboplatin, and Sodium Thiosulfate for Patients With Central Nervous System (CNS) Embryonal or Germ Cell Tumors Unknown status USA 0
NCT01217437 Phase II Irinotecan + Temozolomide Bevacizumab + Irinotecan + Temozolomide Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Completed USA | NZL | CAN | AUS 1
NCT01331135 Phase I Sirolimus Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors Completed USA 0
NCT01356290 Phase II Thalidomide Fenofibrate Etoposide Bevacizumab Celecoxib Cyclophosphamide + Cytarabine Metronomic and Targeted Anti-angiogenesis Therapy for Children With Recurrent/Progressive Medulloblastoma (MEMMAT) Recruiting USA | SWE | NOR | FRA | ESP | DNK | AUT 1
NCT01878617 Phase II Vismodegib Cisplatin + Cyclophosphamide + Vincristine Sulfate Gemcitabine + Pemetrexed Disodium A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma Active, not recruiting USA | NZL | CAN | AUS 0
NCT01977677 Phase Ib/II Temozolomide Plerixafor Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Completed USA 0
NCT01999270 Phase I Bevacizumab + Irinotecan Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors Completed USA 0
NCT02040376 Phase III Metformin Placebo Controlled Double Blind Crossover Trial of Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma Completed CAN 0
NCT02100891 Phase II Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid Tumors Completed USA 0
NCT02301039 Phase II Pembrolizumab A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas Completed USA 0
NCT02304458 Phase Ib/II Ipilimumab + Nivolumab Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas Completed USA | CAN 0
NCT02332889 Phase Ib/II Decitabine Poly ICLC Phase I/II Decitabine/Vaccine Therapy in Relapsed/Refractory Pediatric High Grade Gliomas/Medulloblastomas/CNS PNETs Terminated USA 0
NCT02372006 Phase Ib/II Afatinib Trial of Afatinib in Pediatric Tumours Completed USA | NLD | ITA | GBR | FRA | ESP | DNK | DEU | CAN | AUT | AUS 1
NCT02390752 Phase Ib/II Pexidartinib PLX3397 in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) Recruiting USA 0
NCT02446431 Phase I Cyclophosphamide Bevacizumab Temsirolimus Valproic acid Metronomic Therapy for Pediatric Patients With Solid Tumors at High Risk of Recurrence Recruiting USA 0
NCT02458339 Phase I Methotrexate Methotrexate Infusion Into Fourth Ventricle in Children With Recurrent Malignant Fourth Ventricular Brain Tumors Completed USA 0
NCT02472392 Phase I Fludarabine Cyclophosphamide Melphalan Busulfan anti-thymocyte globulin Study To Examine Toxicity Of Allogeneic Stem Cell Transplantation For Relapsed Or Therapy Refractory Ewings Sarcoma Completed USA 0
NCT02502708 Phase I Indoximod Temozolomide Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Primary Malignant Brain Tumors Completed USA 0
NCT02644291 Phase I Mebendazole Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors Completed USA 0
NCT02748135 Phase Ib/II TB-403 A Two-Part Study of TB-403 in Pediatric Subjects With Relapsed or Refractory Medulloblastoma Completed USA 0
NCT03130959 Phase II Ipilimumab + Nivolumab Nivolumab An Investigational Immuno-therapy Study of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Patients With High Grade Primary CNS Malignancies (CheckMate 908) Completed USA | SWE | POL | NOR | NLD | ISR | GBR | FRA | ESP | DEU | CAN | BRA | AUS 2
NCT03155620 Phase II Tazemetostat Larotrectinib LY3023414 Vemurafenib Palbociclib Olaparib Ulixertinib Erdafitinib Selumetinib Ensartinib Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) Recruiting USA | CAN | AUS 1
NCT03173950 Phase II Nivolumab Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers Recruiting USA 0
NCT03213678 Phase II LY3023414 Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial) Active, not recruiting USA 1
NCT03387020 Phase I Ribociclib Everolimus + Ribociclib Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors Completed USA 0
NCT03434262 Phase I Ribociclib + Trametinib Filgrastim + Gemcitabine + Ribociclib Ribociclib + Sonidegib SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Completed USA 0
NCT03581240 Expanded access Eflornithine An Intermediate Expanded Use Trial of DFMO Available USA 0
NCT03598244 Phase I Savolitinib Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors Recruiting USA | CAN 0
NCT03652545 Phase I MultiTAA-specific T cells Multi-antigen T Cell Infusion Against Neuro-oncologic Disease (REMIND) Recruiting USA 0
NCT03698994 Phase II Ulixertinib Ulixertinib in Treating Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) Active, not recruiting USA 1
NCT03709680 Phase I Irinotecan + Palbociclib + Temozolomide Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors Active, not recruiting USA | TUR | SWE | SVK | POL | NLD | ITA | ISR | HUN | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BGR | BEL | ARG 2
NCT03838042 Phase Ib/II Entinostat + Nivolumab INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies (INFORM2 NivEnt) Recruiting SWE | NLD | FRA | DEU | CHE | AUT | AUS 0
NCT03860207 Phase Ib/II Hu3F8-BsAb Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3F8-BsAb) in Patients With Relapsed/Refractory Neuroblastoma, Osteosarcoma and Other Solid Tumor Cancers Terminated USA 0
NCT03893487 Phase I CUDC-907 Fimepinostat in Treating Brain Tumors in Children and Young Adults (PNOC016) Active, not recruiting USA | CHE 0
NCT03904862 Phase Ib/II Silmitasertib Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery Suspended USA 0
NCT04023669 Phase I Filgrastim Pegfilgrastim Cyclophosphamide + Prexasertib Gemcitabine + Prexasertib Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors Active, not recruiting USA 0
NCT04049669 Phase II Cyclophosphamide + Etoposide + Indoximod Indoximod + Lomustine + Temozolomide Indoximod + Temozolomide Indoximod Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG Recruiting USA 0
NCT04315064 Phase I MTX110 Infusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults With Recurrent Medulloblastoma Recruiting USA 0
NCT04334863 Phase I WP1066 AflacST1901: Peds WP1066 Completed USA 0
NCT04402073 Phase II Cisplatin + Lomustine + Vincristine Sulfate Cisplatin + Lomustine + Sonidegib + Vincristine Sulfate Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma (PersoMed-I) Active, not recruiting NLD | ITA | FRA | ESP | DEU | CHE | AUT | AUS 0
NCT04541082 Phase I ONC206 Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms Recruiting USA 0
NCT04743661 Phase II Bevacizumab + Irinotecan + Omburtamab I-131 + Temozolomide Omburtamab I-131 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma Active, not recruiting USA 0
NCT04978727 Phase I SurVaxM A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma Recruiting USA | CAN 0
NCT05064306 Expanded access Omburtamab I-131 131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young Adults Available USA 0
NCT05096481 Phase II PEP-CMV + Temozolomide PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma Recruiting USA 0
NCT05106296 Phase I Cyclophosphamide + Etoposide + Ibrutinib + Indoximod Chemo-immunotherapy Using Ibrutinib Plus Indoximod for Patients With Pediatric Brain Cancer Recruiting USA 0
NCT05135975 Phase II Cabozantinib A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors Recruiting USA 0
NCT05429502 Phase Ib/II Ribociclib + Temozolomide + Topotecan Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors Recruiting USA | ITA | GBR | FRA | ESP | DEU | AUS 1
NCT06161519 Phase Ib/II PLX038 PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications Recruiting USA 0
NCT06466798 Phase I Methotrexate + Nivolumab Azacitidine + Nivolumab Fourth Ventricular Administration of Immune Checkpoint Inhibitor (Nivolumab) and Methotrexate or 5-Azacytidine for Recurrent Medulloblastoma, Ependymoma, and Other CNS Malignancies Recruiting USA 0
NCT06624371 Phase I Atovaquone Atovaquone Combined with Radiation in Children with Malignant Brain Tumors (AflacBT2303) Recruiting USA 0
NCT06639607 Phase Ib/II Nivolumab + PEP-CMV + Temozolomide PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma (PRiME II) Not yet recruiting USA 0