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| Molecular Profile | BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R |
| Therapy | Vemurafenib |
| Indication/Tumor Type | melanoma |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R | melanoma | predicted - resistant | Vemurafenib | Clinical Study - Cohort | Actionable | In a clinical study, a melanoma patient harboring a BRAF V600 mutation developed resistance-associated mutations, MAP2K1 V60E, NRAS T58I, and NRAS Q61R, after 18 weeks of treatment with Zelboraf (vemurafenib) (PMID: 24265153). | 24265153 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24265153) | The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma. | Full reference... |