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Molecular Profile | JAK2 V617F |
Therapy | Imatinib |
Indication/Tumor Type | myeloid leukemia |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
JAK2 V617F | myeloid leukemia | resistant | Imatinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed mouse myeloid cells over expressing JAK2 V617F were resistant to Gleevec (imatinib) in culture (PMID: 21224473). | 21224473 |
PubMed Id | Reference Title | Details |
---|---|---|
(21224473) | Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease. | Full reference... |