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| Molecular Profile | PTEN loss |
| Therapy | A66 |
| Indication/Tumor Type | glioblastoma |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN loss | glioblastoma | resistant | A66 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, A66 did not inhibit tumor growth in a PTEN-null cell line xenograft model of glioblastoma (PMID: 21668414). | 21668414 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21668414) | A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. | Full reference... |