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| Molecular Profile | RET M918T |
| Therapy | AZD1480 |
| Indication/Tumor Type | medullary thyroid carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RET M918T | medullary thyroid carcinoma | sensitive | AZD1480 | Preclinical - Cell culture | Actionable | In a preclinical study, AZD1480 reduced phosphorylation of RET and downstream effectors, and inhibited growth and increased apoptosis of a medullary thyroid cancer cell line harboring RET M918T in culture (PMID: 23056499). | 23056499 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (23056499) | AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines. | Full reference... |