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Molecular Profile | RET C634W |
Therapy | AZD1480 |
Indication/Tumor Type | thyroid cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET C634W | thyroid cancer | sensitive | AZD1480 | Preclinical - Cell culture | Actionable | In a preclinical study, AZD1480 reduced phosphorylation of RET and downstream effectors, and inhibited growth and increased apoptosis of a thyroid cancer cell line harboring RET C634W in culture (PMID: 23056499). | 23056499 |
PubMed Id | Reference Title | Details |
---|---|---|
(23056499) | AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines. | Full reference... |