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Molecular Profile | MSH2 inact mut |
Therapy | Baicalein |
Indication/Tumor Type | endometrial adenocarcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MSH2 inact mut | endometrial adenocarcinoma | sensitive | Baicalein | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Baicalein selectively induced cell death in an endometrial adenocarcinoma cell line with MSH2 inactivation in culture, and induced apoptosis and tumor shrinkage in MSH2-deficient endometrial adenocarcinoma cell line xenograft models (PMID: 27262172). | 27262172 |
PubMed Id | Reference Title | Details |
---|---|---|
(27262172) | A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies. | Full reference... |