Therapy Detail
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| Therapy Name | Baicalein |
| Synonyms | |
| Therapy Description |
Baicalein is a plant-derived small molecule that binds to Msh2 and mismatched DNA and inhibits the interaction between Msh2 and Chk1/Atm, resulting in increased double-strand breaks and cell death in mismatch repair-deficient tumor cells (PMID: 27262172), and induces DDIT4 expression, which leads to inhibition of mTORC1 activity (PMID: 25543165, PMID: 32800561). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Baicalein | Baicalein is a plant-derived small molecule that binds to Msh2 and mismatched DNA and inhibits the interaction between Msh2 and Chk1/Atm, resulting in increased double-strand breaks and cell death in mismatch repair-deficient tumor cells (PMID: 27262172), and induces DDIT4 expression, which leads to inhibition of mTORC1 activity (PMID: 25543165, PMID: 32800561). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MSH2 inact mut | colon cancer | sensitive | Baicalein | Preclinical | Actionable | In a preclinical study, treatment with Baicalein resulted in decreased growth of azoxymethane/dextran sodium sulfate-induced colon tumors in a MSH2-deficient mouse model (PMID: 27262172). | 27262172 |
| MSH2 inact mut | endometrial adenocarcinoma | sensitive | Baicalein | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Baicalein selectively induced cell death in an endometrial adenocarcinoma cell line with MSH2 inactivation in culture, and induced apoptosis and tumor shrinkage in MSH2-deficient endometrial adenocarcinoma cell line xenograft models (PMID: 27262172). | 27262172 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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