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Molecular Profile PTEN loss
Therapy BLZ945
Indication/Tumor Type glioblastoma
Response Type no benefit

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN loss glioblastoma no benefit BLZ945 Preclinical Actionable In a preclinical study, BLZ945 resulted in limited benefit in transgenic mouse models of glioblastoma harboring a loss of PTEN (PMID: 27199435). 27199435
PubMed Id Reference Title Details
(27199435) The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Full reference...