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| Molecular Profile | PTEN loss |
| Therapy | BLZ945 |
| Indication/Tumor Type | glioblastoma |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN loss | glioblastoma | no benefit | BLZ945 | Preclinical | Actionable | In a preclinical study, BLZ945 resulted in limited benefit in transgenic mouse models of glioblastoma harboring a loss of PTEN (PMID: 27199435). | 27199435 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27199435) | The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. | Full reference... |