Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Molecular Profile | TP53 loss |
| Therapy | BLZ945 |
| Indication/Tumor Type | glioblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 loss | glioblastoma | sensitive | BLZ945 | Preclinical | Actionable | In a preclinical study, treatment with BLZ945 demonstrated some efficacy, specifically a 56% tumor reduction, in transgenic mouse models of glioblastoma with a loss of TP53 (PMID: 27199435). | 27199435 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27199435) | The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. | Full reference... |