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Molecular Profile | TP53 loss |
Therapy | BLZ945 |
Indication/Tumor Type | glioblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 loss | glioblastoma | sensitive | BLZ945 | Preclinical | Actionable | In a preclinical study, treatment with BLZ945 demonstrated some efficacy, specifically a 56% tumor reduction, in transgenic mouse models of glioblastoma with a loss of TP53 (PMID: 27199435). | 27199435 |
PubMed Id | Reference Title | Details |
---|---|---|
(27199435) | The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. | Full reference... |