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Molecular Profile | KIT P551_V555delinsTL |
Therapy | Sorafenib |
Indication/Tumor Type | gastrointestinal stromal tumor |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT P551_V555delinsTL | gastrointestinal stromal tumor | sensitive | Sorafenib | Preclinical - Pdx | Actionable | In a preclinical study, Nexavar (sorafenib) inhibited Erk signaling, induced apoptosis, resulted in tumor growth inhibition in patient derived xenograft models of gastrointestinal stromal tumor harboring KIT P551_V555delinsTL (PMID: 19139124). | 19139124 |
PubMed Id | Reference Title | Details |
---|---|---|
(19139124) | Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor. | Full reference... |