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| Molecular Profile | TP53 R249S |
| Therapy | CP-31398 |
| Indication/Tumor Type | hepatocellular carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 R249S | hepatocellular carcinoma | sensitive | CP-31398 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with CP-31398 resulted in decreased proliferation, increased apoptosis, and cell-cycle arrest in a hepatocellular carcinoma cell line harboring TP53 R249S in culture, and inhibited tumor growth in xenograft models (PMID: 26250460). | 26250460 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (26250460) | CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo. | Full reference... |