Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Molecular Profile | APC wild-type |
Therapy | TASIN-1 |
Indication/Tumor Type | colorectal cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC wild-type | colorectal cancer | resistant | TASIN-1 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TASIN-1 did not inhibit survival of APC wild-type colorectal cancer cells in culture or in cell line xenograft models (PMID: 27798265). | 27798265 |
PubMed Id | Reference Title | Details |
---|---|---|
(27798265) | Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. | Full reference... |