Therapy Detail
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| Therapy Name | TASIN-1 |
| Synonyms | |
| Therapy Description |
TASIN-1 is a small molecule that selectively inhibits growth of cancer cells expressing truncated APC through inhibition of cholesterol biosynthesis (PMID: 27798265, PMID: 31070915). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| TASIN-1 | TASIN-1 is a small molecule that selectively inhibits growth of cancer cells expressing truncated APC through inhibition of cholesterol biosynthesis (PMID: 27798265, PMID: 31070915). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC wild-type | colorectal cancer | resistant | TASIN-1 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TASIN-1 did not inhibit survival of APC wild-type colorectal cancer cells in culture or in cell line xenograft models (PMID: 27798265). | 27798265 |
| APC G1416* | colorectal cancer | sensitive | TASIN-1 | Preclinical - Cell culture | Actionable | In a preclinical study, TASIN-1 inhibited survival of colorectal cancer cell lines harboring APC G1416* in culture (PMID: 27798265). | 27798265 |
| APC E1309* | colorectal cancer | sensitive | TASIN-1 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TASIN-1 efficiently inhibited survival of colorectal cancer cells harboring APC E1309* in culture and in cell line xenograft models (PMID: 27798265). | 27798265 |
| APC Q1131* APC Q1303* | colorectal cancer | sensitive | TASIN-1 | Preclinical - Cell culture | Actionable | In a preclinical study, TASIN-1 inhibited survival of colorectal cancer cells harboring APC Q1131* and APC Q1303* in culture (PMID: 27798265). | 27798265 |
| APC Q1338* | colorectal cancer | sensitive | TASIN-1 | Preclinical - Cell culture | Actionable | In a preclinical study, TASIN-1 inhibited survival of colorectal cancer cell lines harboring APC Q1338* in culture (PMID: 27798265). | 27798265 |
| APC E853* APC K1555* | colorectal cancer | sensitive | TASIN-1 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TASIN-1 efficiently inhibited survival of colorectal cancer cells harboring APC E853* and APC K1555* in culture and inhibited tumor growth in xenograft models (PMID: 27798265). | 27798265 |
| APC inact mut | colorectal cancer | sensitive | TASIN-1 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, TASIN-1 efficiently inhibited survival of colorectal cancer cell lines harboring APC truncation mutations in culture and in cell line xenograft models (PMID: 27798265). | 27798265 |
| APC L1488* | colorectal cancer | sensitive | TASIN-1 | Preclinical - Cell culture | Actionable | In a preclinical study, TASIN-1 inhibited survival of colorectal cancer cells harboring APC L1488* in culture (PMID: 27798265). | 27798265 |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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