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Molecular Profile | FGFR2 over exp |
Therapy | Aprutumab ixadotin |
Indication/Tumor Type | colorectal cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FGFR2 over exp | colorectal cancer | sensitive | Aprutumab ixadotin | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Aprutumab ixadotin (BAY1187982) inhibited survival of colorectal cancer cells with over expressing Fgfr2 in culture, and suppressed tumor growth in cell line xenograft models (PMID: 27543601). | 27543601 |
PubMed Id | Reference Title | Details |
---|---|---|
(27543601) | Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors. | Full reference... |