Therapy Detail
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| Therapy Name | Aprutumab ixadotin |
| Synonyms | |
| Therapy Description |
Aprutumab ixadotin (BAY1187982) is a monoclonal FGFR2 antibody in conjugation with a derivative of auristatin, which may target FGFR2-expressing tumor cells for cytotoxicity (PMID: 27543601). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Aprutumab ixadotin | BAY1187982|FGFR2-ADC | FGFR2 Antibody 3 | Aprutumab ixadotin (BAY1187982) is a monoclonal FGFR2 antibody in conjugation with a derivative of auristatin, which may target FGFR2-expressing tumor cells for cytotoxicity (PMID: 27543601). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR2 dec exp | breast cancer | resistant | Aprutumab ixadotin | Preclinical - Cell culture | Actionable | In a preclinical study, Aprutumab ixadotin (BAY1187982) did not inhibit growth of breast cancer cells with very low Fgfr2 expression level in culture (PMID: 27543601). | 27543601 |
| FGFR2 positive | breast cancer | sensitive | Aprutumab ixadotin | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, Aprutumab ixadotin (BAY1187982) inhibited survival of Fgfr2 positive breast cancer cell lines in culture, and suppressed tumor growth in both cell line and patient-derived xenograft models (PMID: 27543601). | 27543601 |
| FGFR2 positive | Advanced Solid Tumor | sensitive | Aprutumab ixadotin | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, sensitivity to Aprutumab ixadotin (BAY1187982) positively correlated with Fgfr2 expression level in a variety of cancer cell lines in culture, and in cell line or patient-derived xenograft models (PMID: 27543601). | 27543601 |
| FGFR2 amp | ovarian cancer | sensitive | Aprutumab ixadotin | Preclinical - Pdx | Actionable | In a preclinical study, Aprutumab ixadotin (BAY1187982) inhibited tumor growth in patient-derived xenograft models of FGFR2 amplified ovarian cancer (PMID: 27543601). | 27543601 |
| FGFR2 over exp | colorectal cancer | sensitive | Aprutumab ixadotin | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Aprutumab ixadotin (BAY1187982) inhibited survival of colorectal cancer cells with over expressing Fgfr2 in culture, and suppressed tumor growth in cell line xenograft models (PMID: 27543601). | 27543601 |
| FGFR2 positive | stomach cancer | sensitive | Aprutumab ixadotin | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, Aprutumab ixadotin (BAY1187982) inhibited survival of gastric cancer cell lines with elevated Fgfr2 expression level in culture, and suppressed tumor growth in cell line or patient-derived xenograft models (PMID: 27543601). | 27543601 |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02368951 | Phase I | Aprutumab ixadotin | Phase I, Dose-escalation Trial of BAY1187982 in Subjects With Advanced Solid Tumors Known to Express Fibroblast Growth Factor Receptor 2 (FGFR2) | Terminated | USA | 2 |
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