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| Molecular Profile | FGFR2 dec exp |
| Therapy | Aprutumab ixadotin |
| Indication/Tumor Type | breast cancer |
| Response Type | resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FGFR2 dec exp | breast cancer | resistant | Aprutumab ixadotin | Preclinical - Cell culture | Actionable | In a preclinical study, Aprutumab ixadotin (BAY1187982) did not inhibit growth of breast cancer cells with very low Fgfr2 expression level in culture (PMID: 27543601). | 27543601 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27543601) | Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors. | Full reference... |