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| Molecular Profile | BRAF V600E |
| Therapy | RO5126766 |
| Indication/Tumor Type | papillary thyroid carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V600E | papillary thyroid carcinoma | sensitive | RO5126766 | Preclinical | Actionable | In a preclinical study, RO5126766 inhibited Mek signaling and increased radioiodide uptake and response in transgenic animal models of papillary thyroid carcinoma driven by BRAF V600E (PMID: 27669459). | 27669459 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27669459) | Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine. | Full reference... |