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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
RET rearrange Sorafenib papillary thyroid carcinoma sensitive detail...
RET rearrange Ponatinib papillary thyroid carcinoma sensitive detail...
PIK3CA E542K MK2206 papillary thyroid carcinoma sensitive detail...
PIK3CA E542K MK2206 + Temsirolimus papillary thyroid carcinoma sensitive detail...
BRAF V600E RO5126766 papillary thyroid carcinoma sensitive detail...
TP53 wild-type Alrizomadlin papillary thyroid carcinoma sensitive detail...
RET fusion Selpercatinib papillary thyroid carcinoma sensitive detail...
BRAF V600E Dabrafenib + Trametinib papillary thyroid carcinoma sensitive detail...
RET fusion Pralsetinib papillary thyroid carcinoma sensitive detail...
BRAF V600E Vemurafenib papillary thyroid carcinoma sensitive detail...
BRAF V600E Dabrafenib papillary thyroid carcinoma sensitive detail...
BRAF K601E Denosumab + Sorafenib papillary thyroid carcinoma predicted - sensitive detail...
MLH1 negative Pembrolizumab papillary thyroid carcinoma sensitive detail...
MSH6 negative Pembrolizumab papillary thyroid carcinoma sensitive detail...
BRAF V600E PIK3CA W11C PIK3CA E542K Dasatinib + Trametinib papillary thyroid carcinoma sensitive detail...
BRAF V600E NRAS Q61K Vemurafenib papillary thyroid carcinoma predicted - resistant detail...
BRAF V600E Binimetinib + Encorafenib papillary thyroid carcinoma sensitive detail...
BRAF V600E Ravoxertinib papillary thyroid carcinoma sensitive detail...
BRAF del exon2-8 BRAF V600E Binimetinib + PF-07799933 papillary thyroid carcinoma predicted - sensitive detail...
BRAF V600E AZD1208 + Vemurafenib papillary thyroid carcinoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT00770263 Phase I Erlotinib + Temsirolimus Erlotinib and Temsirolimus for Solid Tumors Completed USA 0
NCT01534897 Phase I Dabrafenib Re-differentiation of Radioiodine-Refractory BRAF V600E-mutant Papillary Thyroid Carcinoma With GSK2118436 Completed USA 0
NCT01677741 Phase I Dabrafenib A Study to Determine Safety, Tolerability and Pharmacokinetics of Oral Dabrafenib In Children and Adolescent Subjects Completed USA | ITA | ISR | GBR | FRA | ESP | DNK | DEU | CAN | AUS 0
NCT01709292 Phase II Vemurafenib Vemurafenib Neoadjuvant Trial in Locally Advanced Thyroid Cancer Active, not recruiting USA 0
NCT01723202 Phase II Dabrafenib + Trametinib Dabrafenib Dabrafenib With or Without Trametinib in Treating Patients With Recurrent Thyroid Cancer Unknown status USA 0
NCT02145143 Phase 0 Vemurafenib Enhancing Radioiodine (RAI) Incorporation Into BRAF Mutant, RAI-Refractory Thyroid Cancers With the BRAF Inhibitor Vemurafenib: A Pilot Study Completed USA 0
NCT02211222 Phase I Lenvatinib An Expanded Access Program With Lenvatinib for the Treatment of Radioiodine-Refractory Differentiated Thyroid Cancer Approved for marketing USA 0
NCT02702388 Phase II Lenvatinib Phase 2 Trial of Lenvatinib (E7080) in Subjects With Iodine-131 Refractory Differentiated Thyroid Cancer to Evaluate Whether an Oral Starting Dose of 20 mg or 14 mg Daily Will Provide Comparable Efficacy to a 24 mg Starting Dose, But Have a Better Safety Profile Completed USA | SWE | ROU | POL | ITA | ISR | GBR | FRA | ESP | DNK | DEU | CAN | BEL | AUS 2
NCT02973997 Phase II Lenvatinib + Pembrolizumab Pembrolizumab and Lenvatinib in Treating Metastatic or Recurrent Differentiated Thyroid Cancer That Cannot Be Removed by Surgery Completed USA 0
NCT03002623 Phase II CUDC-907 CUDC-907 Treatment in People With Metastatic and Locally Advanced Thyroid Cancer Terminated USA 0
NCT03215095 Phase I Durvalumab RAI Plus Immunotherapy for Recurrent/Metastatic Thyroid Cancers Active, not recruiting USA 0
NCT03244956 Phase II Trametinib Dabrafenib + Trametinib Efficacy of MEK (Trametinib) and BRAFV600E (Dabrafenib) Inhibitors With Radioactive Iodine (RAI) for the Treatment of Refractory Metastatic Differentiated Thyroid Cancer (MERAIODE) Unknown status FRA 0
NCT03319628 Phase I XMT-1536 First-in-Human Study of XMT-1536 in Cancers Likely to Express NaPi2b Active, not recruiting USA 0
NCT03469011 Phase I Imatinib A Study to Try to Bring Back Radioiodine Sensitivity in Patients With Advanced Thyroid Cancer. Recruiting CAN 0
NCT03732495 Phase II Denosumab + Lenvatinib Study of the Efficacy of Lenvatinib Combined With Denosumab in the Treatment of Patients With Predominant Bone Metastatic Radioiodine Refractory Differentiated Thyroid Carcinomas (LENVOS) Unknown status FRA 0
NCT03753919 Phase II Durvalumab + Tremelimumab Durvalumab Plus Tremelimumab for the Treatment of Patients With Progressive, Refractory Advanced Thyroid Carcinoma -The DUTHY Trial (DUTHY) Terminated ESP 0
NCT03914300 Phase II Cabozantinib + Ipilimumab + Nivolumab Testing the Combination of Cabozantinib, Nivolumab, and Ipilimumab (CaboNivoIpi) for Advanced Differentiated Thyroid Cancer Active, not recruiting USA 0
NCT04321954 Phase II Lenvatinib Lenvatinib in Locally Advanced Invasive Thyroid Cancer Recruiting USA 0
NCT04462471 Phase I Copanlisib + Vemurafenib Vemurafenib Plus Copanlisib in Radioiodine-Refractory (RAIR) Thyroid Cancers Completed USA 0
NCT04731467 Phase Ib/II CM-24 + Nivolumab CM-24 + Nab-paclitaxel + Nivolumab A Study of CM24 in Combination With Nivolumab in Adults With Advanced Solid Tumors Active, not recruiting USA | ISR | ESP 0
NCT04759911 Phase II Selpercatinib Selpercatinib Before Surgery for the Treatment of RET-Altered Thyroid Cancer Active, not recruiting USA 0
NCT05500508 Phase Ib/II AMXT1501 + Eflornithine Oral AMXT 1501 Dicaprate in Combination With IV DFMO Active, not recruiting USA | AUS 0
NCT05620134 Phase Ib/II JK08 A Study of JK08, an IL-15 Antibody Fusion Protein Targeting CTLA-4, in Patients With Unresectable Locally Advanced or Metastatic Cancer Active, not recruiting ESP | BEL 0
NCT05660954 Phase II Cabozantinib Cabozantinib In Advanced Radioactive-Iodine Refractory Differentiated Thyroid Cancer. (CABOTHYROID) Active, not recruiting ESP 0
NCT06007924 Phase II Defactinib + RO5126766 A Study of Avutometinib and Defactinib in People With Thyroid Cancer Recruiting USA 0
NCT06440850 Phase II Cobimetinib + Vemurafenib Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation Recruiting USA 0
NCT06475989 Phase III Dabrafenib + Trametinib Cabozantinib Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer Recruiting USA 0